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Chiral SeparationEnantioselective HPLC – Method Development
Selected advanced topics for HPLC experts
The seminar focuses on updated and modern approaches for developing an enantioselective method based on the lecturer’s first-hand experience. The classification and application of various chiral (enantioselective) stationary phases are discussed and presented using test cases.
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Issues to be covered
The following issues will be covered:
- Principles of chiral resolution by chiral (enantioselective) stationary phases
- Similarity and differences between various chiral stationary phases
- NP and RP separations in chiral chromatography: advantages and pitfalls
- Limitations in use of organic solvents in NP and RP enantioselective chromatography
- Influence of:
- mobile phase composition
- pH
- temperature
- column type
- etc
- on the chromatographic performance
- Strategy of enantioselective method development for a comparatively simple molecule with only one chiral center (case study)
Who should attend
- Analytical chemists with experience in HPLC or related techniques who work in:
- Quality Control
- Analytical laboratories
- R&D
- Bachelor, master or PhD students who wish to learn and experience modern analytical enantioselective methods
About The Lecturer
Vladimir Ioffe
Vladimir Ioffe, Ph.D., Scientific Expert, Lecturer and Advisor in Pharmaceuticcal
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