This course provides knowledge for structure elucidation of small molecules (drugs, pesticides, natural products, etc.) by combined liquid chromatography–tandem mass spectrometry (LC–MS–MS). We study the fragmentation of positively and negatively charged even-electron ions in MS–MS, and discuss identification strategies, both from data-acquisition and from data-processing point of view. Next to lectures and time for questions and discussion, the Course provides exercises in order to practice spectral interpretation.

The course consists of five daily sessions. Each session consists of:

• a maximum of 3 hours of online presentations and discussion
• at maximum 1 hour of homework to work on interpretation exercises (except after the last session). The homework is an essential part of the course!

The exercises should be worked on between the online sessions with great care and attention as if you would be in a classroom with the teacher present. One should divide time over the various exercises and not spend more than 1 hour in total!

Each session consists of:

• An interactive discussion on the exercises of the previous session (except in the first one).
• Two or three presentations, presentations can be freely interrupted for questions and/or discussions. Just attract my attention.
• Short interactive exercises during the presentations.
• Two 10 min breaks between the parts of the online session (to get coffee and to fulfill other
  Needs).

The course manual contains:

• Copies of (most of) the visual material shown during the course
• Additional (supplemental) material which deepens the course material and provides additional information at some points, but which cannot be discussed because of time limitations
• A set of exercises, which will be used during the course.

The course manual is in English

Recording of the online sessions in whatever way or form is not permitted.
Reproducing or sharing the course material and/or the online sessions is not permitted.