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Category: Analytical Chemistry: The Israel Analytical Chemistry Society , Bioforum International
Chiral Recognition and Separation Mechanisms
Lecturer: Nelu Grinberg, Ph.D
Date: January 22nd, 2007
Location: Lev Hakongressim, Kiryat Weizman, Ness Ziona
Course Language: Hebrew
Chiral Recognition and Separation Mechanisms
 
Category: Analytical Chemistry: The Israel Analytical Chemistry Society
Course Name: Chiral Recognition and Separation Mechanisms
Lecturer: Nelu Grinberg, Ph.D
Duration: Day Course
Date: January 22nd, 2007
Hours: 09:00 – 18:00, including lunch
Registration: 
Location: Lev Hakongressim, Kiryat Weizman, Ness Ziona
Price: 1,550 NIS + VAT
Credit Points: 1
SKU: 1
 

The course will focus on specific interactions between the enantiomeric analytes and each specific chiral stationary phase, rather than the techniques used to separate enantiomers. This approach will allow the participants to understand the strategies for development of a separation of enantiomers. The conditions to achieve each type of interaction will be presented. 

Issues to be covered
  • Introduction
  • Separation of Enantiomers through the Formation of Diastereomers
  • Main Types of Molecular Interactions leading to Enantiomeric Separation and Thermodynamics Aspects of Enantiomeric Separation.
    • H-Bonds
    • Inclusion complexes
    • Charge transfer
  • Mixed types of interactions
    • Polysaccharide Phases
    • Antibiotic Phases 
    • Protein Phases
  • Ligand Exchange
  • Tailor-made Sorbents
  • Chiral Mobile Phases
  • Strategies for method development in chiral separation
   
Prof. Nelu Grinberg, Ph.D.
Senior Principal Scientist
Boehringer Ingelheim Pharmaceuticals, Inc.
Chemical Development, Process Development Laboratory
Ridgefield, Connecticut, USA

Prof. Dr. Nelu Grinbergis a Senior Principal Scientist in the Chemical Development Department at Boehringer Ingelheim Pharmaceuticals in Ridgefield, Connecticut, USA.  Prior to this, he worked for sixteen years in the Analytical Department at Merck Research Laboratories in Rahway, NJ, where he was a Senior Research Fellow.  He has authored and coauthored over 70 publications, including articles and book chapters.  He is currently on the editorial board of the Journal of Liquid Chromatography and Related Techniques and is a Co-editor of the Advances in Chromatography series. He obtained his Ph.D. in Chemistry from the Technical University of Lasi in Romania. He conducted post­doctoral research with Professor Barry Kargerat Northeastern University and with Professor Emanuel Gil-Av at The Weizmann Institute of Science in Rehovot, Israel.

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