Retrieving compound identity by LC-MS-MS technology

מרצה: Dr. Wilfried Niessen
תאריך: 2, 3 יולי 2019
מיקום הקורס: קראון פלזה תל אביב, רח' הירקון 145 ת"א
שפת הקורס: אנגלית
קטגוריה: כימיה אנליטית
משך הפעילות: 2 ימי לימודים מלאים
שעות:  9:00-17:00
התכנסות והרשמה: 9:00 - 8:30
עלות: 4,300 ש"ח + מע"מ
נקודות זכות: 2
מק''ט: 19215

על הקורס

This two-day course provides knowledge for structure elucidation of small molecules (drugs, pesticides, natural products, etc.) by combined liquid chromatography–tandem mass spectrometry (LC–MS–MS).
We study the fragmentation of positively and negatively charged even-electron ions in MS–MS, and discuss identification strategies, both from data-acquisition and from data-processing point of view. Next to lectures and time for questions and discussion, the Course provides exercises in order to practice spectral interpretation.


קהל היעד

Researchers involved in structure elucidation and/or confirmation of identity, with at least 6 months experience in LC–MS. People who want to extend their knowledge and understanding of mass spectrometry.


התועלת שתופק

 - Insight in fragmentation reactions of even-electron ions
 - Insight in structure elucidation strategies
 - Interpretation of MS–MS mass spectra


תכני הקורס

Day 1

9:00  Introduction. Ionization and Fragmentation. Exercises.
10:15  Coffee Break
10:30  General Aspects of Fragmentation. Exercises.
12:30  Lunch
13:30  Exercises. MS Strategies for Structure Elucidation – 1. Exercises.
15:15  Coffee Break
15:30  Fragmentation of Even-Electron ions – 1. Oxygen Compounds. Exercises. 
17:00  End of the first day
Day 2

9:00  Fragmentation of Even-Electron ions – 2. Oxygen compounds. Exercises.
10:15  Coffee Break
10:30  Fragmentation of Even-electron Ions – 3. Nitrogen Compounds. Exercises 
12:30  Lunch
13:30  Fragmentation of Even-electron Ions – 4. Nitrogen Compounds Exercises 
15:30  Coffee Break
15:45  MS Strategies for Structure Elucidation – 2.
17:00  End of the Course


אודות המרצה

Dr. Wilfried Niessen

Dr. Wilfried Niessen has more than 20 years of experience as a researcher and project manager in the field of liquid chromatography - mass spectrometry. Since 1996, he worked as an independent consultant for his company hyphen MassSpec. Between 2002 and 2014 , he was (part-time) extraordinary professor in bioanalytical mass spectrometry at the Faculty of Science of the Vrije Universiteit in Amsterdam.